Gong Chen Lab @ Nankai / 南开大学陈弓课题组
恭喜李国兴博士的研究成果被ACS CATALYSIS接受。

恭喜李国兴博士的研究成果被ACS CATALYSIS接受。

https://pubs.acs.org/doi/10.1021/acscatal.8b04079

Photoredox-mediated Minisci-type Alkylation of N-Heteroarenes with Alkanes with High Methylene Selectivity

ACS Catal., Just Accepted Manuscript
DOI: 10.1021/acscatal.8b04079
Publication Date (Web): November 15, 2018
Copyright © 2018 American Chemical Society

Abstract

We report a highly efficient and chemoselective Minisci-type alkylation reaction of N-heteroarenes with alkanes under the reagent control of a hypervalent iodine oxidant PFBI-OH. In addition to the high reactivity, PFBI-OH demonstrated high steric sensitivity for H abstrac-tion of alkanes. This reaction is selective for more sterically accessible secondary C-H bonds over weaker tertiary C-H bonds. High selectiv-ity toward penultimate methylene groups was observed for a wide range of acyclic alkanes.


Article classification: 新闻资讯
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