Gong Chen Lab @ Nankai / 南开大学陈弓课题组

115. Bioconjugation via Hetero-selective Clamping of Two Amines with ortho-Phthalaldehyde.

Xin Chu, Bo Li, Hao-Yang Liu, Xiaowei Sun, Xiaochen Yang, Gang He, Chuanzheng Zhou, Weimin Xuan, Shu-Lin Liu*, and Gong Chen*

Angew. Chem., Int. Ed. 2023, e202212199.

114. Synthesis of N-acyl sulfenamides via copper catalysis and their use as S-sulfenylating reagents of thiols.

Ziqian Bai, Shiyang Zhu, Yiyao Hu, Peng Yang, Xin Chu, Gang He, Hao Wang*, and Gong Chen*. Nat. Commun. 2022, 13, 6445.

DOI: 10.1038/s41467-022-34223-7  ^ Highlighted by X-mol

113. Preface – Special topic in asymmetric C–H functionalization (editorial as guest editor).

Gong Chen*, and Shigeki Matsunaga*, Synthesis 2022, 54, 4690-4690.

DOI: 10.1055/s-0040-1720049

112. Hypervalent-iodine promoted selective cleavage of C(sp3)–C(sp3) bonds in ethers.

Yaxin Wang*, Qin He, Cehui Cao, Peng Wang, Gong Chen*, and Matthias Beller*, Org. Chem. Front. 2022, 9, 5592-5598.

DOI: 10.1039/d2qo01114j

111. Palladium-Catalyzed Methionine-Facilitated β and γ C(sp3)–H Arylation of N-Terminal Aliphatic Amino Acids of Peptides

Xiangxiang Chen, Bo Li, Huarong Tong, Liping Qi, Gang He, Gong Chen. Chin. J. Chem. 2022, 40, 2502-2506.

110. Introduction to ‘Synthesis and chemical biology of macrocycles’ (editorial as guest editor).

Gong Chen, Monika Raj, and Andrei Yudin. RSC Chem. Biol. 2022, 3, 993-993.

DOI: 10.1039/d2cb90018a

109. Ruthenium-Catalyzed Pyridine-Directed Aryl C–H Glycosylation with Glycosyl Chlorides.

Shaokun Cai, Qikai Sun, Quanquan Wang, Gang He* and Gong Chen*. J. Org. Chem. 2022, 87, 8811–8818.

108. Construction of Complex Macromulticyclic Peptides via Stitching with Formaldehyde and Guanidine.

Bo Li+, Zhao Wan+, Hanliang Zheng, Shaokun Cai, Hanwen Tian, Hong Tang, Xin Chu, Gang He, Dong-Sheng Guo, Xiao-Song Xue*, and Gong Chen*. (+co-first author)  

J. Am. Chem. Soc. 2022, 144, 10080–10090.

107. Iron-Catalysed Reductive Cross-Coupling of Glycosyl Radicals for the Stereoselective Synthesis of C-glycosides.

Quanquan Wang+, Qikai Sun+, Yi Jiang, Huixing Zhang, Lu Yu, Changlin Tian, Gong Chen*, & Ming Joo Koh* Nat. Synth. 2022, 1, 235–244. (+co-first author)

106. Extendable Stapling of Unprotected Peptides via Crosslinking Two Amines with o-Phthalaldehyde.

Bo Li, Lan Wang, Xiangxiang Chen, Xin Chu, Hong Tang, Jie Zhang, Gang He, Li Li*, and Gong Chen* Nat. Commun. 2022, 13, 311.

105. Synthesis of 2-Deoxy-C-Glycosides via Iridium-Catalyzed sp2 and sp3 C–H Glycosylation with Unfunctionalized Glycals.

Wanjun Zhu, Qikai Sun, Huixing Zhang, Hai Chang, Hui-Xing Zhang, Quanquan Wang, Gong Chen*, and Gang He*. Chin. J. Chem. 2022, 40, 571-576.

104. Arene C–H Iodination Using 2-Nitrophenyl Iodides as the Iodinating Reagents (highlight)
Huarong Tong and Gong Chen*.
Chin. J. Org. Chem. 2021, 41, 4103-4104. DOI: 10.6023/cjoc202100077

103. Construction of Peptide Macrocycles via Palladium-Catalyzed Multiple S-Arylation: An Effective Strategy to Expand the Structural Diversity of Crosslinkers.
Xin Chu, Linhua Shen, Bo Li, Peng Yang, Chengzhuo Du, Xiaoye Wang, Gang He, Samir Messaoudi*, and Gong Chen*.
Org. Lett. 2021, 23, 8001–8006.
102. Solid Phase Synthesis of Thioether-linked Peptide Macrocycles via Palladium-Catalyzed Intramolecular S-Arylation and S-Alkenylation.
Peng Yang, Chao Zhang, Bo Li, Gang He, and Gong Chen*.
Asian J. Org. Chem. 2021, 10, 2888-2891.
^^ Invited contribution for a special issue

101. Tunable System for Electrochemical Reduction of Ketones and Phthalimides.
Yaxin Wang*, Jianyou Zhao, Qiuping Zhao, Jian Zhang, and Gong Chen.
Chin. J. Chem. 2021, 39, 3297-3302.
100. Nitrene-mediated P–N Coupling Under Iron Catalysis
Ziqian Bai, Fangfang Song, Hao Wang,* Wangxing Cheng (本科生), Shiyang Zhu, Yi Huang, Gang He, and  Gong Chen*
CCS Chem. 2021, 3, 2538-2546. DOI: 10.31635/ccschem.021.202101056.
99. Stereoselective Synthesis of C-Vinyl Glycosides via Palladium-Catalyzed C–H Glycosylation of Alkenes
Qikai Sun, Huixing Zhang, Quanquan Wang, Tianjiao Qiao, Gang He,* and Gong Chen*
Angew. Chem., Int. Ed. 2021, 60, 19620-19625. DOI: 10.1002/anie.202104430 and 10.1002/ange.202104430

98. Iridium-catalyzed intermolecular N—N coupling for hydrazide synthesis using N-benzoyloxycarbamates as acyl nitrene precursor
Fangfang Song, Shiyang Zhu, Hao Wang,* and Gong Chen*
Chin. J. Org. Chem. 2021, 41(10), 4050-4058. DOI: 10.6023/cjoc202105045.

97. Photoredox-Mediated Mono- and Difluorination of Remote Unactivated Methylene C(sp3)–H Bonds of N-Alkyl Sulfonamides
Zhiqiang Deng, Zhenxiang Zhao, Gang He, Gong Chen*
Org. Lett. 2021, 23, 3631-3635. DOI: 10.1021/acs.orglett.1c01020.

96. β-Lactam Synthesis via Copper-Catalyzed Directed Aminoalkylation of Unactivated Alkenes with Cyclobutanone O-Benzoyloximes
Heng Zhang, Xiaoyan Lv, Hanrui Yu (本科生), Zibo Bai, Gong Chen*,  and Gang He*
Org. Lett. 2021,23, 3620-3625. DOI: 10.1021/acs.orglett.1c01007.

95. Streamlined Construction of Peptide Macrocycles via Palladium-catalyzed Intramolecular S-Arylation in Solution and on DNA
Peng Yang, Xuan Wang, Bo Li, Yixuan Yang, Jingfeng Yue, Yanrui Suo, Huarong Tong, Gang He, Xiaojie Lu*, and Gong Chen*
Chem. Sci., 2021,12, 5804-5810. DOI:10.1039/D1SC00789K.

94. Chiral Bicyclo[2.2.2]octane-FusedCyclopentadienyl Rhodium Complexes: Synthesis and Potential Use in Asymmetric C-H Activation
Yi Huang, Gong Chen*
Chin. J. Org. Chem. 2021, 41, 420～422 DOI: 10.6023/cjoc202100002 (Highlight)
93. Construction of peptide macrocycles via radical-mediated intramolecular C-H alkylations.
Xiafei Hu+, Xiangxiang Chen+, Bo Li, Gang He, and Gong Chen*.  (+co-first author)
Org. Lett. 2021, 23, 716-721, DOI: 10.1021/acs.orglett.0c03940
92. Nitrene-mediated Intermolecular N-N coupling for Efficient Synthesis of Hydrazides.
Hao Wang, Hoimin Jung, Fangfang Song, Shiyang Zhu, Danye Chen (本科生), Gang He, Sukbok Chang*, and Gong Chen*.
Nat. Chem. 2021, 13, 378-385. DOI: 10.1038/s41557-021-00650-0.
91. Enantioselective Alkylamination of Unactivated Alkenes under Copper Catalysis.
Zibo Bai, Heng Zhang, Hao Wang*, Hanrui Yu (本科生), Gong Chen*, and Gang He*
J. Am. Chem. Soc. 2021, 143, 1195-1202. DOI: 10.1021/jacs.0c12333
90. A Rapid and Sensitive Method for Chiroptical Sensing of -Amino Acids via Click-like Labeling with o-Phthaladehyde and p-Toluenethiol.
Bo Li+, Jie Zhangi+, Li Li*, and Gong Chen* (+co-first author)
Chem. Sci. 2021, 12, 2504-2508. DOI: 10.1039/D0SC05749E [ChemRxiv. Preprint. https://doi.org/10.26434/chemrxiv.12671144.v1]
89. Cooperative Stapling of Native Peptides at Lysine and Tyrosine or Arginine with Formaldehyde.
Bo Li, Hong Tang, Aneta Turlik, Zhao Wan, Xiao-Song Xue, Li Li, Xiaoxiao Yang, Jiuyuan Li, Gang He， K.N. Houk*, and Gong Chen*
Angew. Chem., Int. Ed. 2021, 60, 6646-6652. DOI: 10.1002/anie.202016267
88. Pd-catalyzed Ortho-Directed C-H glycosylation of arenes with glycosyl chloride donors via N-linked auxiliaries.
Quanquan Wang, Wanjun Zhu, Qikai Sun, Gang He*, and Gong Chen*.
Chin. J. Chem. 2020, 39, 571-576. DOI: 10.1002/cjoc.202000500
87. Synthesis of Cyclophane-braced Peptide Macrocycles via Palladium-catalyzed Intramolecular C(sp3)-H arylation of N-methyl Alanine at C-Termini.
Xinghua Li+, Liping Qi+, Bo Li, Zhenxiang Zhao, Zhiqing Deng, Gang He, and Gong Chen*
Org. Lett. 2020, 22, 6209-6213. DOI: 10.1021/acs.orglett.0c02342
86. Construction of Cyclophane-braced Peptide Macrocycle via Palladium-catalyzed Picolinamide-directed Intramolecular C(sp2)-H Arylation.
Boyang Han, Bo Li, Liping Qi, Peng Yang, Gang He, and Gong Chen*
Org. Lett. 2020, 22, 6879–6883. DOI: 10.1021/acs.orglett.0c02422
85. Copper-catalyzed ortho-C(sp2)-H amination of benzamides and picolinamides with alkylamines using oxygen as green oxidant.
Qiong Li,* Jie Huang, Gong Chen, and Shui-Bo Wang,
Org. Biomol. Chem. 2020,18, 4802-4814 DOI: 10.1039/D0OB00784F

84. Post-assembly Modifications of Peptides via Metal-catalyzed C-H Functionalization (review).
Huarong Tong, Bo Li, Guoxing Li, Gang He, and Gong Chen*
CCS Chemistry, 2020, 2, 1979-1820.
83. Palladium-catalyzed O- and N-glycosylation with Glycosyl Chlorides
Shuang An, Quanquan Wang, Wanjun Zhu, Gang He*, and Gong Chen*.
CCS Chemistry, 2020, 2, 1821–1829. DOI: 10.31635/ccschem.020.202000445
82. Total Synthesis of C--Mannosyl Tryptophan via Palladium-Catalyzed C–H Glycosylation.
Quanquan Wang, Shuang An, Wanjun Zhu, Qianyi Zhou, Shoufei Zhu, Gang He,* and Gong Chen*
CCS Chemistry, 2020, 2, 1729–1736. DOI: 10.31635/ccschem.020.202000380
81. Synthesis of Non-classical Heteroaryl C-Glycosides via Minisci-type Alkylation of N‑Heteroarenes with 4-Glycosyl-dihydropyridines
Qingbing Wang, Juan Duan, Pingping Tang, Gong Chen* and Gang He*
80. Cysteine-Specific Protein Modification, Multi-functionalization and Di-sulfide Bridging Using 3-Bromo-5-Methylene Pyrrolones.
Yingqian Zhang, Chuanlong Zang, Guoce An, Mengdi Shang, Zenghui Cui, Gong Chen, Zhen Xi, and Chuanzheng Zhou*.
Nature Communications. 2020, 755. DOI: 10.1038/s41467-020-14757-4
78. A Modular C—H Methylation Reaction via Catellani Strategy
Hua-Rong Tong,  Gang He, and Gong Chen*
Chin. J. Org. Chem. 2019, 39, 3306～3307. (Highlight)
77. Photoredox-Mediated Remote C(sp3)–H Heteroarylation of N-Alkyl Sulfonamides
Zhiqiang Deng, Guo-Xing Li*, Gang He and Gong Chen*
J. Org. Chem., 2019, 84, 15777-15787. DOI: 10.1021/acs.joc.9b02502. [Dedicated to  the 100th anniversary of Nankai University].
74. Copper-catalyzed Intramolecular Aminoperfluoroalkylation Reaction of O-Homoallyl Benzimidates
Zhang, Heng; Mou, Xueqing; Chen, Gong*; He, Gang*
Acta Chim. Sinica, 2019, 77(9): 884-888. [Dedicated to  the 100th anniversary of Nankai University]
73. Minisci C-H Alkylation of N-Heteroarene with Aliphatic Alcohol via β-Scission of Alkoxy Radical
Xiafei Hu, Guo-Xing Li,* Gang He, and Gong Chen*
Org. Chem. Front., 2019, 6, 3205-3209. [Dedicated to  the 100th anniversary of Nankai University]
72. Three-Component Vicinal-Diarylation of Alkenes via Directed Transmetalation of Arylboronic Acids
Yun Zhang, Gong Chen*, and Dongbing Zhao*
Chem. Sci., 2019,10, 7952-7957.
71. Palladium-Catalyzed C−H Glycosylation for Synthesis of C-Aryl Glycosides
Quanquan Wang, Shuang An, Zhiqiang Deng, Wanjun Zhu, Zeyi Huang (本科生), Gang He*, and Gong Chen*
Nature Catal., 2019, 2, 793-800. [Dedicated to  the 100th anniversary of Nankai University].
70. Palladium-Catalyzed Amide-Directed Enantioselective Carboboration of Unactivated Alkenes Using a Chiral Monodentate Oxazoline Ligand
Zibo Bai, Sujuan Zheng, Ziqian Bai, Fangfang Song, Hao Wang, Qian Peng,* Gong Chen,* and Gang He*
ACS Catal., 2019, 9, 6502-6509. DOI: 10.1021/acscatal.9b01350. [Dedicated to  the 100th anniversary of Nankai University].
69. Selective Removal of Aminoquinoline Auxiliary by IBX Oxidation
Zhi-guo Zhang*, Xiang Li Meng-meng, Song Ya-meng, Wan Dan, Zheng Gui-sheng Zhang* and Gong Chen*
J. Org. Chem., 2019 JUST ACCEPTED.
68. Copper(I)-catalyzed enantioselective intramolecular aminotrifluoromethylation of O-homoallyl-benzimidates
Xue-Qing Mou, Feng-Ming Rong, Heng Zhang, Gong Chen,* and Gang He*
Org. Lett., 2019, 21, 4657-4661. [Dedicated to  the 100th anniversary of Nankai University]
67. Construction of Natural-Product-Like Cyclophane-Braced Peptide Macrocycles via sp3 C−H Arylation
Bo Li, Xinghua Li, Boyang Han, Zhijie Chen, Xuekai Zhang, Gang He, and Gong Chen*
J. Am. Chem. Soc., 2019, 141, 9401-9407. [Dedicated to  the 100th anniversary of Nankai University]
66. Iridium-Catalyzed Enantioselective C(sp3)−H Amidation Controlled by Attractive Noncovalent Interactions
Hao Wang, Yoonsu Park, Ziqian Bai, Sukbok Chang*, Gang He*, and Gong Chen*
J. Am. Chem. Soc., 2019, 141, 7194-7201. DOI: 10.1021/jacs.9b02811. [Dedicated to  the 100th anniversary of Nankai University]
65. DPPF-mediated C―H arylation of arenes with aryl iodides for synthesis of biaryl linkages
Qingbing Wang, Zhengwei Guo, Gong Chen*  and Gang He*
Acta Physica Sinica, 2019, DOI: 10.3866/PKU.WHXB201811044. [Dedicated to  the 100th anniversary of Nankai University]
64. Synthesis of Reversible PAD4 Inhibitors via Copper-Catalyzed C−H Arylation of Benzimidazole
Zhengwei Guo, Lai Shi, Bo Wang, Gang He,* Yanming Wang,* and Gong Chen*
Science China Chemistry, 2019, 62, 592-596. DOI: 10.1007/s11426-018-9409-3. [Dedicated to  the 100th anniversary of Nankai University]
63. Synthesis of 2,3-Fused Indoline Aminals via 4+2 Cycloaddition Reaction of Benzazetidines with Indoles
Zi-bo Bai, Hua-rong Tong, Hao Wang, Gong Chen* and Gang He*
Chinese Journal of Chemistry, 2019, 37, 119-125. DOI: 10.1002/cjoc.201800483. Just Accepted Manuscript
62. Photoredox-mediated Minisci-type Alkylation of N-Heteroarenes with Alkanes with High Methylene Selectivity
Guo-xing Li, Xia-fei Hu, Gang He* and Gong Chen*
ACS Catal., 2018, 8, 11847-11853. DOI: 10.1021/acscatal.8b04079
61. Photoredox-mediated Remote C(sp3)-H Heteroarylation of Free Alcohols
Guo-xing Li, Xia-fei Hu, Gang He* and Gong Chen*
Chem. Sci., 2019,10, 688-693. DOI: 10.1039/C8SC04134B
60. Pd(0)-Catalyzed Bidentate Auxiliary Directed Enantioselective Benzylic C-H Arylation of 3-Arylpropanamides Using BINOL Phosphoramidite Ligand
Hua-Rong Tong, Sujuan Zheng, Xinghua Li, Zhiqiang Deng, Hao Wang, Gang He*, Qian Peng*, and Gong Chen*
ACS Catal., 2018, 8, 11502–11512. DOI: 10.1021/acscatal.8b03654

59. Epimerization of Tertiary Carbon Centers via Reversible Radical Cleavage of Unactivated C(sp3)-H Bonds
Yaxin Wang+, Xiafei Hu+, Cristian A. Morales-Rivera, Guo-Xing Li, Xin Huang (本科生), Gang He*, Peng Liu*, and Gong Chen*
J. Am. Chem. Soc., 2018, 140, 9678-9684. DOI:10.1021/jacs.8b05753
^ Highlighted by ChemBeanGo: https://www.chembeango.com/zixun/26380
58. Efficient preparation of β-hydroxy aspartic acid and its derivatives
Long Liu, Bo Wang, Cheng Bi (本科生), Gang He and Gong Chen
Chinese Chem. Lett., 2018, 29, 1113-1115. DOI:10.1016/j.cclet.2018.05.012
57. Photoredox‐Mediated Minisci Alkylation of N‐Heteroarenes using Carboxylic Acids and Hypervalent Iodine
Junhua Wang, Guo‐Xing Li, Gang He and Gong Chen
Asian J. Org. Chem., 2018, 7, 1307-1310. DOI:10.1002/ajoc.201800197
56. Palladium-Catalyzed ortho C−H Arylation of Benzaldehydes Using ortho-Sulfinyl Aniline Transient Auxiliary
Delong Mu, Gang He, and Gong Chen*
Chem. Asian J., 2018, 13，2423-2426. DOI: 10.1002/asia.201800581
55. Total Synthesis of Teixobactin and Its Stereoisomers
Org. Chem. Front., 2018, 5, 1431-1435. DOI: 10.1039/C8QO00145F

54. Radical C–H Arylation of Oxazoles with Aryl Iodides: dppf as an Electron-Transfer Mediator for Cs2CO3
53. Palladium-Catalyzed Amide-Directed Enantioselective Hydrocarbofunctionalization of Unactivated Alkenes
Using a Chiral Monodentate Oxazoline Ligand.
Hao Wang , Zibo Bai, Tangqian Jiao, Zhiqiang Deng, Huarong Tong, Gang He*, Qian Peng*, and Gong Chen*
J. Am. Chem. Soc., 2018, 140, 3542-3546.
^ Highlighted by X-MOL: http://www.x-mol.com/news/13106
52. Radical-mediated β-C(sp3)−H Amidation of Alcohols: Facile Synthesis of Oxazoline and 2-Aminoalcohols.
Xue-Qing Mou, Xiang-Yu Chen, Gong Chen*, and Gang He*.
Chem. Commun. 2018, 54, 515. DOI: 10.1039/c7cc08897c.
51. A General Strategy for Synthesis of Cyclophane-Braced Peptide Macrocycles via Palladium-Catalyzed Intramolecular sp3 C−H Arylation.
Xuekai Zhang, Gang Lu, Meng Sun, Madhu Mahankali, Yanfei Ma, Mingming Zhang, Wangde Hua, Yuting Hu, Qingbing Wang, Jinghuo Chen, Gang He*, Xiangbing Qi*,
Weijun Shen*, Peng Liu* and Gong Chen*.
Nature Chem. 2018, online. doi:10.1038/s41557-018-0006-y
50. A Unified Photoredox-Catalysis Strategy for C(sp3)−H Hydroxylation and Amidation Using Hypervalent Iodine.
Guo-Xing Li, Cristian A Morales-Rivera, Fang Gao, Yaxin Wang, Gang He, Peng Liu*, Gong Chen*.
Chem. Sci. 2017, 8, 7180-7185. DOI: 10.1039/c7sc02773g.
49. 8-Quinolinamine, 5-methoxy.
Gang He, and Gong Chen*
e-ROS. 2017
48. Iridium-Catalyzed ortho-C(sp2)–H Amidation of Benzaldehydes with Organic Azides
Delong Mu, Xinmou Wang, Gong Chen*, Gang He*.
J. Org. Chem., 2017, 82, 4497–4503. DOI: 10.1021/acs.joc.7b00531.
47. Halogen-Bond-Promoted Photoactivation of Perfluoroalkyl Iodides: A Photochemical Protocol for Perfluoroalkylation Reactions.
Yaxin Wang, Junhua Wang, Guo-Xing Li, Gang He, and Gong Chen*.
Org. Lett. 2017, 19, 1442-1445. DOI: 10.1021/acs.orglett.7b00375.
46. Palladium-Catalyzed β-C−H Arylation of Aliphatic Carboxamides with Sterically Hindered Aryl Iodides Using -Sulfinyl Aniline Auxiliaries.
Delong Mu, Fang Gao, Gong Chen*, and Gang He*.
ACS Catal., 2017, 7, 1880–1885. DOI: 10.1021/acscatal.6b03661
44. Synthesis of a Suite of Click-compatible Sugar Analogs for Probing Carbohydrate Metabolism.
Bo Wang, Daniel McClosky, Charlie Anderson*, and Gong Chen*.
Carbohydrate Research. 2016, 433, 54-62, DOI: 10.1016/j.carres.2016.07.012.
43. Photoredox-Mediated Minisci C–H Alkylation of N-Heteroarenes Using Boronic Acids and Hypervalent Iodine.
Guo-Xing Li, Cristian A Morales-Rivera, Yaxin Wang, Fang Gao, Gang He, Peng Liu,* and Gong Chen*.
Chem. Sci. 2016, 7, 6407-6412, DOI: 10.1039/C6SC02653B
^ Highlighted by Synfact 2016, 12, 1081
42. 1,2,3,4-Tetrahydroquinoline synthesis via Palladium-Catalyzed Picolinamide-Directed Remote C–H Iodination of Arylpropylamines.
William A Nack, Xingmou Wang, Bo Wang, Gang He*, and Gong Chen*.
Beilstein J. Org. Chem. 2016, 12, 1243-1249. DOI:10.3762/bjoc.12.119 .
^^ Invited contribution for a themed issue
41. Benzazetidine Synthesis via Palladium-Catalyzed Intramolecular C−H Amination.
Gang He,* Gang Lu, Zhengwei Guo, Peng Liu,* and Gong Chen*.
Nature Chem. 2016, 8, 1131-1136. DOI: 10.1038/nchem.2585
^ Highlighted by Synfact 2017, 13, 243
^ Highlighted by Phys.org http://phys.org/news/2016-08-synthesis-benzazetidine-compounds.html
40. Syntheses and Transformations of α-Amino Acids via Palladium-Catalyzed Auxiliary-Directed sp3 C−H Functionalization.
Gang He, Bo Wang, William A Nack, and Gong Chen*.
Acc. Chem. Res. 2016, 49, 635-645, DOI: 10.1021/acs.accounts.6b00022.
39. Total Synthesis of Mannopeptimycins α and β
Bo Wang, Yunpeng Liu, Rui Jiao, Yiqing Feng, Qiong Li, Chen Chen, Long Liu, Gang He, and Gong Chen*.
J. Am. Chem. Soc. 2016, 138, 3926-3932, DOI: 10.1021/jacs.6b01384.
^ Highlighted by C&E News 2016, 94 (11), 10.
38. Palladium-Catalyzed Arylation of Methylene C(sp3)−H Bonds at Room Temperature: Desymmetrization of Simple Cycloalkyl Carboxylic Acids.
William A Nack, Bo Wang, Xiang Wu, Rui Jiao, Gang He, and Gong Chen*.
Org. Chem. Frontier 2016, 3, 561-564, DOI: 10.1039/C5QO00421G.
^^ Invited contribution for a themed issue
37. Palladium-Catalyzed -C(sp3)−H Arylation of Phthaloyl Alanine with Hindered Aryl Iodides: Synthesis of Complex -Aryl -Amino Acids.
Xuekai Zhang, Gang He*, and Gong Chen*.
Org. Biomol. Chem. 2016, 14, 5511-5515, DOI: 10.1039/C5OB02580J
^^ Invited contribution for a themed issue
36. A Visible-Light-Promoted Radical Reaction System for Azidation and Halogenation of Tertiary Aliphatic C−H Bonds.
Yaxin Wang, Guo-Xing Li, Guohui Yang, Gang He, and Gong Chen*.
Chem. Sci. 2016, 7, 2679-2683. DOI: 10.1039/C5SC04169D.
^ Highlighted by Organic Chemistry Portal: http://www.organic-chemistry.org/Highlights/2017/16January.shtm
35. The Click-compatible Sugar 6-Deoxy-alkynyl Glucose is Metabolically Incorporated into Arabidopsis Root Hair Tips and Arrests Their Growth.
Daniel D. McClosky, Bo Wang, Gong Chen, Charles T. Anderson*.
Phytochemistry 2016, 123, 16-24. DOI: 10.1016/j.phytochem.2016.01.007.
34. Palladium-Catalyzed Alkylation of Unactivated C(sp3)−H Bonds with Primary Alkyl Iodides at Room Temperature: Facile Synthesis of β-Alkyl α-Amino Acids.
Bo Wang, Xiang Wu, Rui Jiao, Shuyu Zhang, William A Nack, Gang He, and Gong Chen*.
Org. Chem. Frontier 2015, 2, 1318-1321. DOI: 10.1039/c5qo00112a.
33. Syntheses of Nitrogen-containing Heterocycles via Palladium-catalyzed Intramolecular Dehydrogenative C-H Amination.
William A. Nack, and Gong Chen*.
Synlett 2015. 26, 2505-2511. DOI: 10.1055/s-0034-1381051.
32. A Versatile Click-Compatible Monolignol Probe to Study Lignin Deposition in Plant Cell Walls.
Jyotsna L. Pandey, Bo Wang, Brett G. Diehl, Tom L. Richard, Gong Chen, Charles T. Anderson*. PLOS ONE 2015, 10, e0121334, DOI:10.1371/journal.pone.0121334
31. Synthesis of α-Alkynyl β-Amino Acids via Palladium-Catalyzed Alkynylation of Unactivated C(sp3)−H Bonds.
Bo Wang, Gang He, Shuyu Zhang, William A Nack, and Gong Chen*. Sci. China Chem. 2015. 58, 1345-1348. DOI: 10.1007/s11426-015-5392-z
30. ATF4 Gene Network Mediates Cellular Response to the Anticancer PAD Inhibitor YW3-56 in Triple Negative Breast Cancer Cells.
Shu Wang, Xiangyun Amy Chen, Jing Hu, Jian-kang Jiang, Yunfei Li, Ka Yim Chan- Salis, Ying Gu, Gong Chen, Craig Thomas, B. Frank Pugh, Yanming Wang*. Mol. Cancer. Ther. 2015, 14, 877-888. DOI: 10.1158/1535-7163.MCT-14-1093-T, PMID: 25612620
29. Pd-catalyzed Mono-selective ortho-C−H Alkylation of N-Quinolyl Benzamides: Evidence for Stereo-retentive Coupling of Secondary Alkyl Iodides.
Shuyu Zhang, Qiong Li, Gang He, William A. Nack, and Gong Chen*.
J. Am. Chem. Soc. 2015, 137, 531-539. DOI: 10.1021/ja511557h, PMID: 25493327
28. Total Synthesis of Hibispeptin A via Pd-Catalyzed C(sp3)−H Arylation with Sterically Hindered Aryl Iodides.
Gang He, Shuyu Zhang, William A. Nack, Ryan Pearson, Javon Rabb-Lynch, and Gong Chen*.
Org. Lett. 2014. 16, 6488-6491, DOI: 10.1021/ol503347d, PMID: 25487778
27. Palladium-Catalyzed Stereoretentive Olefination of Unactivated C(sp3)−H Bonds with Vinyl Iodides at Room Temperature: Synthesis of -Vinyl -Amino Acids.
Bo Wang, Chengxi Lu, Shuyu Zhang, Gang He, William A. Nack, and Gong Chen*
Org. Lett. 2014, 16, 6260-6263, DOI: 10.1021/ol503248f, PMID: 25412205.
26. 1-Iodocyclohexene.
William A. Nack, and Gong Chen* e-EROS. 2014.
25. Palladium-Catalyzed Trifluoroacetate-Promoted Mono-Arylation of β Methyl Group of Alanine at Room Temperature: Synthesis of β-Arylated α-Amino Acids through Sequential C−H Functionalization.
Bo Wang, William A. Nack, Gang He, Shuyu Zhang, and Gong Chen*.
Chem. Sci. 2014, 5, 3952-3957. DOI: 10.1039/C4SC01545B.
23. Palladium-Catalyzed Picolinamide-Directed Halogenation of ortho C−H Bonds of Benzylamine Substrates.
Chengxi Lu, Shu-Yu Zhang, Gang He, William A. Nack, and Gong Chen*.
Tetrahedron 2014, 70, 4197-4203. DOI: 10.1016/j.tet.2014.02.070.
^^ Invited contribution for a themed issue
24. Palladium-Catalyzed Picolinamide-Directed Acetoxylation of Unactivated γ C(sp3)−H Bonds of Alkylamines.
Qiong Li, Shuyu Zhang, Gang He, William A. Nack, and Gong Chen*.
Adv. Synth. Cat. 2014, 356, 1544-1548. DOI: 10.1002/adsc.201400121
^^ Invited contribution for a themed issue
22. Copper-Catalyzed Picolinamide-Directed ortho Amination of ortho-C−H Bonds of Anilines with Alkylamines at Room Temperature.
Qiong Li, Shu-Yu Zhang, Gang He, Zhaoyan Ai, William A. Nack, and Gong Chen*.
Org. Lett. 2014, 16, 1764-1767. DOI: 10.1021/ol500464x, PMID: 24588126
21. Stereoselective Synthesis of -Alkylated -Amino Acids via Palladium-Catalyzed Alkylation of Methylene C(sp3)−H Bonds.
Shu-Yu Zhang, Qiong Li, Gang He, William A. Nack, and Gong Chen*.
J. Am. Chem. Soc. 2013, 135, 12135−12141. DOI: 10.1021/ja406484v, PMID: 23919290.
^ Highlighted by Synfact 2013, 9, 1196. ^ Highlighted by Organic Chemistry Portal: http://www.organic-chemistry.org/Highlights/2014/28July.shtm
20. Use of a Readily Removable Auxiliary Group for the Synthesis of Pyrrolidones by the Palladium-Catalyzed Intramolecular Amination of Unactivated C(sp3)−H Bonds.
Gang He, Shu-Yu Zhang, William A. Nack, and Gong Chen*.
Angew. Chem., Int. Ed. 2013, 52, 11124−11128. DOI: 10.1002/anie.201305615, PMID: 24038874
^ Highlighted by Organic Chemistry Portal: http://www.organic-chemistry.org/Highlights/2014/08September.shtm
19. Experimental and Computational Studies of Anion Recognition by Pyridine-Functionalized Calixarenes.
Nicola Y. Edwards,* Fang Liu, and Gong Chen.
Supramolecular Chem. 2013, 25, 481−489. DOI: 10.1080/10610278.2013.794946.
18. Iodination of Remote ortho-C−H Bonds of Arenes via Picolinamide-Directed Electrophilic Aromatic Substitution: A Streamlined Synthesis Strategy for Tetrahydroquinolines.
William A. Nack, Gang He, Shu-Yu Zhang, Chengxi Lu, and Gong Chen*.
Org. Lett. 2013, 15, 3440-3443. DOI: 10.1021/ol4015078, PMID: 23786364
17. Synthesis of Phenanthridines via Palladium-Catalyzed Picolinamide-Directed Sequential C−H Functionalization.
Ryan Pearson, Shuyu Zhang, Gang He, Nicola Edwards, and Gong Chen*.
Beilstein J. Org. Chem. 2013, 9, 891-899. DOI: 10.3762/bjoc.9.102, PMID: 23766804
^^ Invited contribution for a themed issue
16. Synthesis of Novel Bivalent Mimetic Ligands for Mannose-6-Phosphate Receptors.
Yunpeng Liu, Jared Marshall, Qiong Li, Nicola Edwards, Gong Chen*.
Bioorg. Med. Chem. Lett. 2013, 23, 2328−2331. DOI: 10.1016/j.bmcl.2013.02.068, PMID: 23473680
15. Palladium-Catalyzed Picolinamide-Directed Alkylation of Unactivated C(sp3)−H Bonds with Alkyl Iodides”
Shuyu Zhang, Gang He, William A. Nack, Yingsheng Zhao, Qiong Li, and Gong Chen*
J. Am. Chem. Soc. 2013, 135, 2124−2127. DOI: 10.1021/ja312277g, PMID: 23350845
^ Editors’ choice, ChemInform 2013, 44, issue 32.
^ Highlighted by Organic Chemistry Portal: http://www.organic-chemistry.org/Highlights/2014/27January.shtm
14. Anticancer PAD inhibitors regulate the autophagy flux and the mammalian target of rapamycin complex 1 activity.
Wang, Y.J., Li, P., Wang, S., Hu, J., Fisher, M., Oshaben, K., Wu, J., Zhao, N., Wang, D., Chen, G.* Wang, Y*.
J. Biol. Chem. 2012, 287, 25941−25953. DOI: 10.1074/jbc.M112.375725, PMID:
^ News coverage by NIH-NCATS: A epigenetic strategy to kill cancer tumors http://www.ncats.nih.gov/news-and-events/features/epigenetic.html
13. Palladium-Catalyzed Alkenylation and Alkynylation of ortho-C(sp2)−H Bonds of Benzylamine Picolinamides.
Yingsheng Zhao, Gang He, William A. Nack, and Gong Chen*
Org. Lett. 2012, 14, 2948−2951. DOI: 10.1021/ol301214u, PMID: 22670792
12. Improved Protocol for Indoline Synthesis via Palladium-Catalyzed Intramolecular C(sp2)−H Amination.
Gang He, Chengxi Lu, Yingsheng Zhao, William A. Nack, and Gong Chen*
Org. Lett. 2012, 14, 2944−2947. DOI: 10.1021/ol301352v, PMID: 22670815
^ Highlighted by Synfact 2012, 8, 1073
11. Efficient Ether Synthesis via Palladium-catalyzed Picolinamide-directed Alkoxylation of Unactivated C(sp3) and C(sp2)−H Bonds at Remote Positions.
Shuyu Zhang, Gang He, Yingsheng Zhao, and Gong Chen*
J. Am. Chem. Soc. 2012, 134, 7313−7316. DOI: 10.1021/ja3023972
^ Highlighted by Organic Chemistry Portal: http://www.organic-chemistry.org/Highlights/2013/28January.shtm
10. Highly Efficient Syntheses of Azetidines, Pyrrolidines and Indolines via Palladium-Catalyzed Intramolecular Amination of C(sp3) and C(sp2)−H Bonds at and Positions.
Gang He, Yingsheng Zhao, Shuyu Zhang, Chengxi Lu, and Gong Chen*.
J. Am. Chem. Soc. 2012, 134, 3−6. DOI: 10.1021/ja210660g
^ Highlighted by Synfact 2012, 8, 0258 ^ Highlighted by Organic Chemistry Portal: http://www.organic-chemistry.org/Highlights/2012/19November.shtm
9. Chemical Synthesis of N-linked Glycans Carrying both Mannose-6-phosphate and GlcNAc-Mannose-6-phosphate Motifs.
Yunpeng Liu, and Gong Chen*
J. Org. Chem. 2011, 76, 8682−8689. DOI: 10.1021/jo2010999
8. Palladium-catalyzed Alkylation of ortho-C(sp2)−H Bonds of Benzylamide Substrates with Alkyl Halides.
Yingsheng Zhao, and Gong Chen*
Org. Lett. 2011, 13, 4850−4853. DOI: 10.1021/ol201930e
7. A class of novel N-isoquinoline-3-carbonyl-l-amino acid benzylesters: Synthesis, anti-tumor evaluation and 3D QSAR analysis.
Meiqing Zheng, Yifan Yang, Ming Zhao*, Xiaoyi Zhang, Jianhui Wu, Gong Chen*, Li Peng, Yuji Wang, and Shiqi Peng*
Eur. J. Med. Chem. 2011, 46, 1672−1681. DOI: 10.1016/j.ejmech.2011.02.017
6. Development of highly effective three-component cytoprotective adjuncts for cisplatin cancer treatment: synthesis and in vivo evaluation in S180-bearing mice.
Yuji Wang, Lei Wei, Ming Zhao*, Shenghui Mei, Meiqing Zheng, Yifan Yang, Hong Wang, Gong Chen* and Shiqi Peng*
Metallomics 2011, 3, 1212−1217. DOI: 10.1039/c1mt00013f
5. A Practical Strategy for Structural Modification of Aliphatic Scaffolds via Palladium-Catalyzed Picolinamide Directed Remote Functionalization of Unactivated C(sp3)−H Bonds: Synthesis of (+)-Obafluorin. Gang He and Gong Chen*
Angew. Chem., Int. Ed. 2011, 50, 5192−5196. DOI: 10.1002/anie.201100984
^ Highlighted by Organic Chemistry Portal: http://www.organic-chemistry.org/Highlights/2012/19March.shtm
4. Chemical Synthesis of a Bis-phosphorylated Mannose-6-Phosphate N-Glycan and its Facile Mono-conjugation with Human Carbonic Anhydrase II for in vivo Fluorescence Imaging.
Yupeng Liu, Yan M Chan, Jianhui Wu, Chen Chen, Alan Benesi, Jing Hu, Yanming Wang, and Gong Chen*
ChemBioChem 2011, 12, 685−690. DOI: 10.1002/cbic.201000785
3. Facile Benzo-ring Construction via Palladium-catalyzed Functionalization of Unactivated sp3 C−H bonds Under Mild Reaction Conditions.
Yiqing Feng, Bradley Landgraf, Shi Liu, Yuji Wang, and Gong Chen*
Org. Lett. 2010, 12, 3414−3417. DOI: 10.1021/ol101220x, PMID: 20583778
^ Highlighted by Organic Chemistry Portal: http://www.organic-chemistry.org/Highlights/2014/28July.shtm
2. Coordination of PAD4 and HDAC2 in the regulation of p53 target gene expression.
Li P, Wang D, Yao H, Doret P, Hao G, Shen Q, Qiu H, Zhang X, Wang Y, Chen, G. Yanming Wang*
Oncogene 2010, 29, 3153−3162. DOI: 10.1038/onc.2010.51
1. Total Synthesis of Celogentin C via Stereoselective C−H Activation.
Yiqing Feng and Gong Chen*
Angew. Chem., Int. Ed. 2010, 49, 958−961. DOI: 10.1002/anie.200905134, PMID: 20029862
^ Highlighted by Organic Chemistry Portal: http://www.organic-chemistry.org/Highlights/2011/21March.shtm
Ph.D. and Postdoc work:
1. Reactivity of Functional Groups on the Protein Surface: Development of Epoxide Probes for Protein Labeling.
Gong Chen, Alexander Heim, Doris Riether, Dominic J. Yee, Yelena Milgrom, Mary Ann Gawinowicz, and Dalibor Sames*.
J. Am. Chem. Soc. 2003, 125, 8130−8133.

2. Design of Optical Switches as Metabolic Indicators: New Fluorogenic Probes for Monoamine Oxidases (MAO A and B).
Gong Chen, Dominic J. Yee, Niko G. Gubernator, and Dalibor Sames*.
J. Am. Chem. Soc. 2005, 127, 4544−4545.

3. A route to cyclic peptides and glycopeptides by native chemical ligation using in situ derived thioesters.
Jiehao Chen, J. David Warren, Bin Wu, Gong Chen, Qian Wan, and Samuel J. Danishefsky*.
Tetrahedron Lett. 2006, 47, 1969−1972.

4. Building complex glycopeptides: Development of a cysteine-free native chemical ligation protocol.
Bin Wu, J. David Warren, Jiehao Chen, Gong Chen, Zihao Hua, and Samuel J. Danishefsky. Angew. Chem. Int. Ed. 2006, 45, 4116−4125.

5. Studies Related to the Relative Thermodynamic Stabilities of C-Terminal Peptidyl Esters of O-Hydroxy Thiophenol: Emergence of a Doable Strategy for Non-Cysteine Ligation Applicable to the Chemical Synthesis of Glycopeptides.
Gong Chen, J. David Warren, Jiehao Chen, Bin Wu, Qian Wan, and Samuel J. Danishefsky. J. Am. Chem. Soc. 2006, 128, 7460−7462.

6. Reiterative Cysteine-based Coupling Leading to Complex, Homogeneous Glycopeptides.
Bin Wu, J. David Warren, Jiehao Chen, Gong Chen, Zihao Hua, and Samuel J. Danishefsky. Tetrahedron Lett. 2006, 47, 5219−5223.

7. Synthesis of the fucosylated biantennary N-glycan of erythropoietin. Bin Wu, Zihao Hua, J. David Warren, Krishnakumar Ranganathan,
Qian Wan, Gong Chen, Zhongping Tan, Jiehao Chen, Atsushi Endo, and Samuel J. Danishefsky. Tetrahedron Lett. 2006, 47, 5577−5579.

8. A Potentially Valuable Advance in the Synthesis of Carbohydrate Based Anticancer Vaccines Through Extended Cycloaddition Chemistry.
Qian Wan, Jiehao Chen, Gong Chen, and Samuel J. Danishefsky. J. Org. Chem. 2006, 71, 8244−8249.

9. Mature Homogeneous Erythropoietin Building Blocks by Chemical Synthesis: The EPO 22-37 Glycopeptide Domain Presenting the Fully N-Linked Dodecasaccharide.
Bin Wu, Zhongping Tan, Gong Chen, Jiehao Chen, Zihao Hua, Qian Wan, Krishnakumar Ranganathan, and Samuel J. Danishefsky. Tetrahedron Lett. 2006, 47, 8009−8011.

10. Mature Homogeneous Erythropoietin Building Blocks by Chemical Synthesis: The EPO 114−166 Glycopeptide Domain Presenting Its O-Linked Glycophorin.
Jiehao Chen, Gong Chen, Bin Wu, Qian Wan, Zhongping Tan, Zihao Hua, and Samuel J. Danishefsky. Tetrahedron Lett. 2006, 47, 8013−8016.

11. Development of Efficient Methods for Accomplishing Cysteine-Free Peptide and Glycopeptide Coupling.
Gong Chen, Qian Wan, Zhongping Tan, Cindy Kan, Krishnakumar Ranganathan, Zihao Hua, and Samuel J. Danishefsky. Angew. Chem. Int. Ed. 2007, 46, 7383−7386.

12. Toward Homogeneous Erythropoietin: Fine Tuning of the C Terminal Acyl Donor in the Chemical Synthesis of the Cys29−Gly77 Glycopeptide Domain. Yu Yuan, Jin Chen, Qian Wan, Zhongping Tan, Gong Chen, Cindy Kan, and Samuel J. Danishefsky. J. Am. Chem. Soc. 2009, 131, 5432−5437.


13. Toward Homogeneous Erythropoietin: Chemical Synthesis of the Ala1−Gly28 Glycopeptide Domain by ‘Alanine’ Ligation. Cindy Kan, John D. Trzupek, Bin Wu, Qian Wan, Gong Chen, Zhongping Tan, Yu Yuan, and Samuel J. Danishefsky. J. Am. Chem. Soc. 2009, 131, 5438−5443.
14. Toward Fully Synthetic Homogeneous β-Human Follicle-Stimulating Hormone (β-hFSH) with a Biantennary N-Linked Dodecasaccharide.
Pavel Nagorny, Bernhard Fasching, Xuechen Li, Gong Chen, Baptiste Aussedat, and Samuel J. Danishefsky. Synthesis of β-hFSH with Chitobiose Units at the Natural Linkage Sites. J. Am. Chem. Soc. 2009, 131, 5792–5799.



Patents
1. Therapeutic compositions and methods of PAD4 inhibitors in cancer and autoimmune diseases. Gong Chen, Yanming Wang, Pingxin Li, Jing Hu, Shu Wang, Yuji Wang. US/ International Pat. App PCT/US2011/058791, WO/2012/061390, 2012.
2. 一种新型大环环肽化合物的合成方法。陈弓，张学楷. 申请公布号 CN 106995483 A 申请公布日 2017.08.01
3. 含有双齿配位基团的氨基酸手性配体、手性催化剂及其对应的制备方法和应用。陈弓，王浩，白子谦，何刚。申请号：201910242142.1